Insomnia

Insomnia Overview

Most adults have experienced insomnia or sleeplessness at one time or another in their lives. An estimated 30%-50% of the general population are affected by insomnia, and 10% have chronic insomnia.

Insomnia is a symptom, not a stand-alone diagnosis or a disease. By definition, insomnia is "difficulty initiating or maintaining sleep, or both" and it may be due to inadequate quality or quantity of sleep. Insomnia is not defined by a specific number of hours of sleep that one gets, since individuals vary widely in their sleep needs and practices. Although most of us know what insomnia is and how we feel and perform after one or more sleepless nights, few seek medical advice. Many people remain unaware of the behavioral and medical options available to treat insomnia.

Insomnia is generally classified based on the duration of the problem. Not everyone agrees on one definition, but generally:

* symptoms lasting less than one week are classified as transient insomnia,

* symptoms between one to three weeks are classified as short-term insomnia, and

* those longer than three weeks are classified as chronic insomnia.

Statistics on Insomnia

Insomnia affects all age groups. Among adults, insomnia affects women more often than men. The incidence tends to increase with age. It is typically more common in people in lower socioeconomic (income) groups, chronic alcoholics, and mental health patients. Stress most commonly triggers short-term or acute insomnia. If you do not address your insomnia, however, it may develop into chronic insomnia.

Insomnia Causes

Insomnia may be caused by a host of different reasons. These causes may be divided into situational factors, medical or psychiatric conditions, or primary sleep problems. Insomnia could also be classified by the duration of the symptoms into transient, short-term, or chronic. Transient insomnia generally last less than seven days; short-term insomnia usually lasts for about one to three weeks, and chronic insomnia lasts for more than three weeks.

Many of the causes of transient and short-term insomnia are similar and they include:

* Jet lag

* Changes in shift work

* Excessive or unpleasant noise

* Uncomfortable room temperature (too hot or too cold)

* Stressful situations in life (exam preparation, loss of a loved one, unemployment, divorce, or separation)

* Presence of an acute medical or surgical illness or hospitalization

* Withdrawal from drug, alcohol, sedative, or stimulant medications

* Insomnia related to high altitude (mountains)

Chronic or long-term insomnia

The majority of causes of chronic or long-term insomnia are usually linked to an underlying psychiatric or physiologic (medical) condition.

Psychological related insomnia

The most common psychological problems that may lead to insomnia include:

* anxiety,

* stress,

* schizophrenia,

* mania (bipolar disorder), and

* depression.

In fact, insomnia may be an indicator of depression. Many people will have insomnia during the acute phases of a mental illness.

Physiological related insomnia

Physiological causes span from circadian rhythm disorders (disturbance of the biological clock), sleep-wake imbalance, to a variety of medical conditions. The following are the most common medical conditions that trigger insomnia:

* Chronic pain syndromes

* Chronic fatigue syndrome

* Congestive heart failure

* Night time angina (chest pain) from heart disease

* Acid reflux disease (GERD)

* Chronic obstructive pulmonary disease (COPD)

* Nocturnal asthma (asthma with night time breathing symptoms)

* Obstructive sleep apnea

* Degenerative diseases, such as Parkinson's disease and Alzheimer's disease (Often insomnia is the deciding factor for nursing home placement.)

* Brain tumors, strokes, or trauma to the brain

High risk groups for insomnia

In addition to the above medical conditions, certain groups may be at higher risk for developing insomnia:

* travelers

* shift workers with frequent changing of shifts

* seniors

* adolescent or young adult students

* pregnant women, and

* menopausal women

Medication related insomnia

Certain medications have also been associated with insomnia. Among them are:

* Certain over-the-counter cold and asthma preparations.

* The prescription varieties of these medications may also contain stimulants and thus produce similar effects on sleep.

* Certain medications for high blood pressure have also been associated with poor sleep.

* Some medications used to treat depression, anxiety, and schizophrenia.

Other causes of insomnia

* Common stimulants associated with poor sleep include caffeine and nicotine. You should consider not only restricting caffeine and nicotine use in the hours immediately before bedtime but also limiting your total daily intake.

* People often use alcohol to help induce sleep, as a nightcap. However, it is a poor choice. Alcohol is associated with sleep disruption and creates a sense of nonrefreshed sleep in the morning.

* A disruptive bed partner with loud snoring or periodic leg movements also may impair your ability to get a good night's sleep.

Primary Sleep Disorders

In addition to the causes and conditions listed above, there are also a number of conditions that are associated with insomnia in the absence of another underlying condition. These are called primary sleep disorders, in which the sleep disorder is the main cause of insomnia. These conditions generally cause chronic or long-term insomnia. Some of the diseases are listed below:

* Idiopathic Insomnia (unknown cause) or childhood insomnia, which start early on in life and results in lifelong sleep problems. This may run in families.

* Central Sleep Apnea. This is a complex disorder. It can be the primary cause of the insomnia itself or it may be caused by other conditions, such as brain injury, heart failure, high altitude, and low oxygen levels.

* Restless leg syndrome (a condition associated with creeping sensations in the leg during sleep that are relieved by leg movement)

* Periodic limb movement disorder (a condition associated with involuntary repeated leg movement during sleep)

* Circadian rhythm disorders (disturbance of the biological clock) which are conditions with unusual timing of sleep (for example, going to sleep later and waking up late, or going to sleep very early and getting up very early).

* Sleep state misperception, in which the patient has a perception or feeling of not sleeping adequately, but there are no objective (polysomnographic or actigraphic) findings of any sleep disturbance.

* Insufficient sleep syndrome, in which the patient's sleep is insufficient because of environmental situations and lifestyle choices, such as sleeping in a bright or noisy room.

* Inadequate sleep hygiene, in which the individual has poor sleep or sleep preparation habits (described in the following treatment section.)

Insomnia Symptoms

Doctors associate a variety of signs and symptoms with insomnia. Often, the symptoms intertwine with those of other medical or mental conditions.

* Some people with insomnia may complain of difficulty falling asleep or waking up frequently during the night. The problem may begin with stress. Then, as you begin to associate the bed with your inability to sleep, the problem may become chronic.

* Most often daytime symptoms will bring people to seek medical attention. Daytime problems caused by insomnia include the following:

o Poor concentration and focus

o Difficulty with memory

o Impaired motor coordination (being uncoordinated)

o Irritability and impaired social interaction

o Motor vehicle accidents because of fatigued, sleep-deprived drivers

* People may worsen these daytime symptoms by their own attempts to treat the symptoms.

o Alcohol and antihistamines may compound the problems with sleep deprivation.

o Others have tried nonprescription sleep aids.

When to Seek Medical Care

When to call the doctor

* A person with insomnia needs a doctor's attention if it lasts longer than three to four weeks, or sooner if it interferes with a person's daytime activities and ability to function.

* Insomnia may be a symptom of another medical or psychological problem, which a patient may need to address first or at the same time.

When to go to the hospital

* Generally, a patient will not be hospitalized for most types of insomnia. However, accidents may result from poor coordination and attention lapse seen with sleep deprivation.

* Worsening pain or increased difficulty breathing at night also may indicate a person need to seek emergency medical care.

Exams and Tests

The doctor will begin an evaluation of insomnia with a good medical history.

* The doctor will seek to identify any medical or psychological illness that may be contributing to the patient's insomnia. A thorough medical history and examination including screening for psychiatric disorders and drug and alcohol use is paramount in evaluation of a patient with sleep problems.

o For example, the patient may be asked about chronic snoring and recent weight gain. This may direct an investigation into the possibility of obstructive sleep apnea. In such an instance, the doctor may request an overnight sleep test (polysomnogram). Sleep studies are frequently done in specialized "sleep labs" by doctors trained in sleep medicine, frequently working under pulmonary (lung) specialists. This test is not part of the routine initial workup for insomnia, however.

o The diary will include the patient's personal assessment of their alertness at various times of the day on two consecutive days within the two week period.

* The Epworth Sleepiness Scale is an example of a validated questionnaire that can be used to assess daytime sleepiness.

* Actigraphy is another technique to assess sleep-wake patterns over time. Actigraphs are small, wrist-worn devices (about the size of a wristwatch) that measure movement. They contain a microprocessor and on-board memory and can provide objective data on daytime activity.

Insomnia Treatment

In general, transient insomnia resolves when the underlying trigger is removed or corrected. Most people seek medical attention when their insomnia becomes more chronic.

The main focus of treatment for insomnia should be directed towards finding the cause. Once a cause is identified, it is important to manage and control the underlying problem, as this alone may eliminate the insomnia. Treating the symptoms of insomnia without addressing the main cause is rarely successful.

The following therapies may be used in conjunction with therapies directed towards the underlying medical or psychiatric cause. They are also the recommended therapies for some of the primary insomnia disorders.

Generally, treatment of insomnia entails both non-pharmacologic (non-medical) and pharmacologic (medical) aspects. It is best to tailor treatment for individual patient based on the potential cause. Studies have shown that combining medical and non-medical treatments typically is more successful in treating insomnia than either one alone.

Non-medical treatment and behavioral therapy

Non-pharmacologic or non-medical therapies are sleep hygiene, relaxation therapy, stimulus control, and sleep restriction. These also referred to as cognitive behavioral therapies.

Sleep hygiene

Sleep hygiene is one of the components of behavioral therapy for insomnia. Several simple steps can be taken to improve a patient's sleep quality and quantity. These steps include:

* Sleep as much as you need to feel rested; do not oversleep.

* Exercise regularly at least 20 minutes daily, ideally 4-5 hours before your bedtime.

* Avoid forcing yourself to sleep.

* Keep a regular sleep and awakening schedule.

* Do not drink caffeinated beverages later than the afternoon (tea, coffee, soft drinks etc.) Avoid "night caps," (alcoholic drinks prior to going to bed).

* Do not smoke, especially in the evening.

* Do not go to bed hungry.

* Adjust the environment in the room (lights, temperature, noise, etc.)

* Do not go to bed with your worries; try to resolve them before going to bed.

Relaxation therapy

Relaxation therapy involves measures such as meditation and muscle relaxation or dimming the lights and playing soothing music prior to going to bed.

Stimulus control

Stimulus control therapy also consists of a few simple steps that may help patients with chronic insomnia.

* Go to bed when you feel sleepy.

* Do not watch TV, read, eat, or worry in bed. Your bed should be used only for sleep and sexual activity.

* If you do not fall asleep 30 minutes after going to bed, get up and go to another room and resume your relaxation techniques.

* Set your alarm clock to get up at a certain time each morning, even on weekends. Do not oversleep.

* Avoid taking long naps in the daytime.

Sleep restriction

Restricting your time in bed only to sleep may improve your quality of sleep. This therapy is called sleep restriction. It is achieved by averaging the time in bed that the patient spends only sleeping. Rigid bedtime and rise time are set, and patient is forced to get up even if they feel sleepy. This may help the patient sleep better the next night because of the sleep deprivation for the previous night. Sleep restriction has been helpful in some cases.

Other simple measures that can be helpful to treat insomnia include:

* Avoid large meals and excessive fluids before bedtime

* Control your environment.

o Light, noise, and elevated room temperature can disrupt sleep. Shift workers and night workers especially must address these factors. Dimming the lights in the bedroom, relaxation, limiting the noise, and avoiding stressful tasks before going to bed may be beneficial. (Refer to sleep hygiene and relaxation therapy above.)

o Avoid doing work in the bedroom that should be done somewhere else. For example, do not work or operate your business out of your bedroom and avoid watching TV, reading books, and eating in your bed.

A person's body's circadian rhythm (biological clock) is particularly sensitive to light. Parents who need to sleep during the day may have to make child care arrangements to allow them to sleep.

Medications and Medical Therapies

There are numerous possible medications to treat insomnia. Generally, it is advised that they should not be used as the only therapy and that treatment is more successful if combined with non-medical therapies. In a study, it was noted that when sedatives were combined with behavioral therapy, more patients were likely to wean off the sedatives than if sedatives were used alone.

* Benzodiazepine sedatives: six of these sedative drugs have been used to treat insomnia. There are reports of subjective improvement of quality and quantity of sleep when using these medications. These include temazepam (Restoril), flurazepam (Dalmane), triazolam (Halcion), estazolam (ProSom, Eurodin), lorazepam (Ativan), and clonazepam (Klonopin).

* Nonbenzodiazepine sedatives: These include eszopiclone (Lunesta), zaleplon (Sonata), and zolpidem (Ambien).

* Melatonin: Melatonin is secreted by the pineal gland, a pea-sized structure at the center of your brain. Melatonin is produced during the dark hours of the day-night cycle (circadian rhythm). Melatonin levels in the body are low during daylight hours. The pineal gland responds to darkness by increasing melatonin levels in the body. This process is thought to be integral to maintaining circadian rhythm. At night, melatonin is produced to help your body regulate your sleep-wake cycles. The amount of melatonin produced by your body seems to decrease as you get older. Melatonin may be beneficial in patients with circadian rhythm problems.

* Ramelteon (Rozerem) is a prescription drug that stimulates melatonin receptors. Ramelteon promotes the onset of sleep and helps normalize circadian rhythm disorders. Ramelteon is approved by the Food and Drug Administration (FDA) for treatment of insomnia characterized by difficulty falling asleep.

* Some antidepressants [for example, amitriptyline (Elavil, Endep) and trazodone (Desyrel)] have been used for the treatment of insomnia in patients with co-existing depression because of some sedative properties. Generally, they may not be helpful for insomnia in people without depression.

* Antihistamines with sedative properties [for example, diphenhydramine (Benadryl) or doxylamine] have also been used in treating insomnia as they may induce drowsiness, but they do not improve sleep and should not be used to treat chronic insomnia.

* Valeriana officinalis (Valerian) is a popular herbal medication used in the United States for treating insomnia, however, to date there are no convincing studies to show any real benefit in patients with chronic insomnia.

Follow-up

Follow the doctor's recommendations for the patient's medical and psychological conditions. The patient will be asked to give their doctor feedback after they have followed a treatment plan.

Often the patient will have more than one option and more than one medication available to help them. A patient should not lose hope if the first medication does not give them the results they want or if they experience side effects or concerns. Report back to a doctor for advice.

Prevention

The following are suggestions to help anticipate and modify situations likely to be associated with insomnia. They are not foolproof, nor will they safeguard the patient from the consequences of sleep deprivation once it has occurred.

Insomnia from jet lag

* Behavioral and short-term drug therapy has been used.

* If you can anticipate a trip, begin to shift your bedtime to coincide with the time schedule in your destination.

* Short-acting tranquilizers (benzodiazepines) have been shown to be useful. Melatonin, a hormone secreted by the pineal gland that regulates our sleep-wake cycles, has also been used.

Insomnia from shift changes

* Behavioral therapy has been useful in modifying the insomnia and symptoms of sleep deprivation in shift workers.

* You should shift your schedules forward in a clockwise direction - from days to evening to night shift - and allow sufficient time to adapt (at least one week) between shift changes.

* Bright light is a potent stimulus to circadian rhythm. Bright light is being examined as a rhythm synchronizer.

* Shift workers should stress the importance of good sleep habits with regular bedtime and awakening.

o Supplemental naps may be necessary to ensure work time alertness.

o Discuss the use of naps with a doctor.

o Some people promote using short-acting sedatives in the first few days following a shift change, but not everyone agrees.

Insomnia from acute stresses

* Stress may be positive or negative, and concerns about sleep may vary. Many stressors will go away with support and reassurance.

* Education about the importance of good sleep habits is also helpful.

* Some people may need short-term treatment with medications. A doctor will often work toward the lowest effective dose with a short-acting sedative to achieve proper sleep.

General recommendations include the following:

* Work to improve your sleep habits.

o Learn to relax. Self-hypnosis, biofeedback and relaxation breathing are often helpful.

o Control your environment. Avoid light, noise, and excessive temperatures. Use the bed only to sleep and avoid using it for reading and watching TV. Sexual activity is an exception.

o Establish a bedtime routine. Fix wake time.

* Avoid large meals, excessive fluid intake, and strenuous exercise before bedtime and reduce the use of stimulants including caffeine and nicotine.

* If you do not fall asleep within 20-30 minutes, try a relaxing activity such as listening to soothing music or reading.

* Limit daytime naps to less than 15 minutes unless directed by your doctor.

o It is generally preferable to avoid naps whenever possible to help consolidate your night's sleep.

o There are certain sleep disorders, however, that will benefit from naps. Discuss this issue with your doctor.

http://www.emedicinehealth.com